![]() ![]() “This innovative approach and effective method for local siRNA delivery could have wide applications including diabetic wound healing, a significant and growing problem across the globe,” said Christine Kelley, Ph.D., division director in the National Institute of Biomedical Imaging and Bioengineering, part of the NIH. The study was supported by National Institutes of Health (NIH) grants EB021750 and AR056138. 16 by the journal Advanced Materials, the researchers demonstrate they did this in a mouse model by “packaging” the siRNA in protective nanoparticles and embedding the particles in a porous polyester urethane scaffold. One of the biggest challenges is delivery - getting siRNA into the cell. Small interfering ribonucleic acids (siRNAs) can block translation of messenger RNA into proteins, including enzymes that regulate the activity of transcription factors, as was done in this work. health care system more than $25 billion a year, according to one estimate. If further animal studies confirm the initial findings, the drug-containing scaffold could provide a new approach to healing chronic wounds, which afflict millions of patients with diabetes and other diseases and cost the U.S. (photo by Susan Urmy)īiomedical and chemical engineers at Vanderbilt University, working with a pathologist, have constructed a sponge-like, biodegradable tissue “scaffold” that releases an enzyme-blocking molecule to indirectly activate endogenous pathways and enhance tissue regeneration and wound healing. ![]() From left, Scott Guelcher, Ph.D., Jeffrey Davidson, Ph.D., Christopher Nelson and Craig Duvall, Ph.D., showed that an enzyme-blocking molecule released by a biodegradable scaffold can enhance wound healing in a mouse model. ![]()
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Abactochromis is unique in the mbuna in having greatly enlarged, lobate lips and several other autapomorphies. ![]() Therefore, we designate it the type species of Abactochromis, new genus. Melanochromis labrosus also does not fit within any other described genus. labrosus is not a Melanochromis, since it lacks the synapomorphic striped color pattern typical of that genus. Although its placement within the mbuna group remains somewhat equivocal, we unambiguously demonstrate that M. labrosus is best considered a species of mbuna. Two features of body coloration (a relatively small number of ocellate spots in the anal fin and a possible polychromatism in one population) suggest that M. labrosus belongs with the mbuna, we review the morphological traits often considered to define the mbuna as a natural group, concluding that none is a uniquely shared specialization. In addition, we extensively survey vertebral counts in the mbuna. labrosus using all obtainable specimens collected since its original description. Melanochromis labrosus is the only one of the 800 or so endemic cichlid species in Lake Malawi whose placement with mbuna or non-mbuna has been disputed on morphological grounds. Intralacustrine dispersion of Malawi cichlids is briefly addressed in appended material. I also describe three new species of haplochromines with three lateral spots and present a key to the three-spot assemblage. I present a detailed phylogenetic analysis of the Cyrtocara livingstonii species-group of ambush predators, and characterize a new species in the group. The remaining major parts of the study are concerned with particular assemblages of haplochromine cichlids in Lake Malawi. ![]() The two (or more) faunal components of Lake Malawi are ecologically distinct. A derived type of anal-fin markings present in a subset of the Malawian fauna is shared with many non-Malawian haplochromines, indicating that the species flock of Lake Malawi is not monophyletic. At a less inclusive phylogenetic level, I examine the controversy over the monophyletic status of the "species flock" of haplochromine cichlids in Lake Malawi. It possesses a distinctive suite of derived characters, but is uniquely primitive among African cichlids in infraorbital morphology and other features. I redescribe this monotypic genus and species and illustrate much of its osteology. With this review as a framework, I argue that the most phylogenetically primitive African cichlid is Heterochromis multidens, a little-known large cichlid from the Zaire River basin. At the most general level, I summarize current morphological evidence that supports cichlid monophyly and the most-inclusive groups of cichlids. Diverse systematic problems at three levels in cichlid phylogeny form the subject matter of this dissertation. The cichlids of Africa present many challenges to the taxonomist. ![]() ![]() ![]() ![]() Every retro game available with an NSO sub (plus the Expansion Pack) The Expansion Pak is installed in a port on top of the Nintendo 64 and replaces the pre-installed Jumper Pak, which is simply a RAMBUS terminator. Guide Nintendo Switch Online - Every NES, SNES, N64, Sega Genesis, Game Boy, And GBA Game Available.260 product ratings - Nintendo 64 Expansion Pak Pack Official N64 Memory Pack OEM Original NUS-007 Red. ago Seen a few posts lately where users experienced crashing and games resetting on their own while using a third party expansion pack.Nintendo 64 Expansion Pak Pack Official N64 Memory Pack OEM Original NUS-007 Red. Scot-free thievery before anyone's eyes.Expansion pak for n64 Nintendo's first-party accessories are mainly transformative system expansions: the 64DD Internet multimedia platform, with a floppy drive, video capture and editor, game building setup, web browser, and online service the controller plus its own expansions for storage and rumble feedback and the RAM-boosting Expansion Pak for big improvements …where to get a cheap 3rd party N64 expansion pak the official ones are 40$ I don't want to pay that much for 4 Mb of ram is there cheaper 3rd option from china 4 14 comments Best Add a Comment mistertimely … and even if you get called out and caught outright lying red-handed, there's no single way for you that any customer can make you pay for and hold you accountable for whatever. Then again, the software-industry is literally the only single industry, where you can outright scam your customers (Early Access) and rip them off overtly (DLCs) and can lie through your teeth – and you still get awarded royally in hundreds of millions if not billions. I think it's just the next developer who successfully tried riding the hype-train and profited from Paradox' image as a in-depth strategic publisher with a shipload of remarkable and already genre-defining titles under its belt. It feels like Romeo really pulled a stunt here – it's more or less a copy-cat of Omertà. So, knowing Omertà, which I actually in fact do very well (I've played the game excessively when it came out, released a bunch of mods for it and was one of its most ardent beta-testers and supporters, wrote both the English and German Wikipedia-article of the game too), I must say The moment I saw the first in-game footage of Empire of Sins, I *knew* they took great effort in borrowing a lot from Omertà, so to speak … To put it simply, EoS feels like a actual scam if you know Omertà. So all in all, the narrative John and Brenda Romero tried to sell – that they made a game from scratch (and came up with that totally unique idea of such a mafia game) – seems like a blatant lie if you consider all this. Like literally, play both games (or watch a Let's play of Omertà) and you see that the whole map looks like a rip-off and especially the in-game fights are virtually largely identical. It's literally some awful uncreative Copy'nPast-job of Omertà - City of Gangsters from the known German Publisher-developer duo Kalypso Media/Haemimont Games. Though Empire of Sins was a huge let-down. How to shoot time-lapse videos in Paradox Games.4Chan's Image Guide- Which Paradox game do I choose?.A full list of guides can be found here.Result: Paradox is Swedish" Websites and Wikis Please use proper spoiler formatting if you are going to discuss spoiler content in non-spoiler threads: >!Paradox is Swedish!<</p> Please mark a thread for spoilers if there's spoilers in the main post or if there's going to be open discussion of spoilers in the comments To avoid spoiling narrative surprises for others, please adhere to the following guidelines: Users may only make one self-promotional submission per week.Īvoid topics on the list of common topics, and do not post topics on the list of banned topics.Ĭontent that breaks the spirit of these rules, or content deemed by the moderators as low-quality, may be removed at moderator discretion. Explanations should be posted as a reddit comment - referencing the title is not enough.Īll giveaways, surveys, and petitions must be approved by the moderators first. General discussion of piracy or leaked content is allowed.Īdhere to the Reddit content policy and the reddiquette.Įxplain what you want people to look at when you post an image. No links to pirated materials, pirated game mods, or key resellers. No memes, image macros, reaction pictures, or similar. Just the title of the post being relevant does not qualify. Hover your mouse over any of the boxes below to view relevant information.Games similar to Paradox titles may also be discussed. about any game published by Paradox Interactive or their partners. This is a sub-reddit for discussion, links, etc. Sales Game Converters Game Mods Flair Guide Wikis Paradox Forums Report Bug Teamspeak Discord Welcome to Paradox Plaza ![]() |